Ipledge Questions and Answers & Essential Answers

If you’re considering starting a treatment with isotretinoin, chances are you have a lot of questions about the ipledge program. As someone who has gone through the process myself, I understand the confusion and uncertainty that can come with it. That’s why I’ve put together this comprehensive guide to answer all your ipledge questions and help you navigate the program with confidence.

Ipledge Questions and Answers

Purpose of iPledge

iPledge is a mandatory program designed to prevent pregnancy in females who are taking isotretinoin. Its main goal is to ensure the safe use of this medication, which is highly effective but carries a risk of serious birth defects if taken during pregnancy.

How Does iPledge Work?

iPledge works by requiring all patients, both males and females, to follow a series of steps before they can receive isotretinoin:

  1. Registration: Patients must register and create an account on the iPledge website. This involves providing personal information, including your name, contact details, and a unique username and password.
  2. Education: Before starting treatment, patients must complete the iPledge education materials, including reading and understanding the information about isotretinoin, its potential side effects, and the importance of contraception.
  3. Pregnancy Testing: On a monthly basis, female patients of childbearing potential are required to complete two negative pregnancy tests. These tests must be performed within a specific timeframe to ensure accurate results.
  4. Contraception: Females must commit to using two forms of contraception or practicing abstinence during the entire course of treatment. One of the methods must be a highly effective form of contraception, such as oral contraceptives or intrauterine devices (IUDs).
  5. Visit with Healthcare Provider: During each monthly visit, female patients must meet with their healthcare provider to discuss any changes in their medical condition, update their medication history, and receive a new prescription for isotretinoin.
  6. Prescription Authorization: Prior to receiving their prescription, patients must access the iPledge system to confirm their agreement to the terms and conditions of the program and answer any required questions.

Who Uses iPledge?


As part of the iPledge program, patients who seek to obtain and use isotretinoin are required to participate. This includes both males and females, as isotretinoin can also have significant health risks for men.

It’s important for patients to understand the potential risks associated with isotretinoin and to follow the guidelines set by iPledge to ensure the safe use of the medication. These guidelines include undergoing regular pregnancy testing, using two forms of contraception, and adhering to monthly visits with healthcare providers.

Healthcare Providers

Healthcare providers play a crucial role in the iPledge program. This includes doctors, nurse practitioners, physician assistants, and any other healthcare professionals who prescribe isotretinoin to their patients.

Before prescribing isotretinoin, healthcare providers must be registered with the iPledge program and complete the necessary training. They are responsible for determining if isotretinoin is an appropriate treatment option for their patients and for educating them about the potential risks and benefits.


Pharmacies also play a vital role in the iPledge program to ensure the safe dispensing of isotretinoin. They must be registered with iPledge and adhere to the program’s requirements and guidelines.

When a patient presents a prescription for isotretinoin, the pharmacy is responsible for verifying that the patient is enrolled in the iPledge program and has met all the necessary requirements. This includes checking that the patient has undergone pregnancy testing, is using two forms of contraception, and has received authorization from their healthcare provider.

By involving patients, healthcare providers, and pharmacies in the iPledge program, it aims to create a comprehensive system that promotes the safe use of isotretinoin and reduces the potential risks of harm to unborn babies.